Been playing Madden for the Wii lately, and it is extremely well done. Give EA credit for going all out here; almost every thing on the football field can be done with the wii mote and nunchuk, from hiking the ball, passing, stiff arms, jukes, power tackling, kicking, etc.
And best of all, it is very intuitive and easy to learn. I was really getting into it, chucking deep bombs and knocking over defenders (the latter is done by shoving your arms forward in a shoving motion). It feels feels very cool to flick you arm forward and watch your QB throw a bomb to the receiver, and to strip fumbles by flicking the Wii mote down.
If you get a Wii and already have Madden, get this one anyway. It plays totally different and might be the best version of Madden this year.
-Rob